Biology Blood
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Question 2 Part B
The 2 blood products I have chosen are platelets and plasma
Platelets
Platelets are small clear cell fragments about 2-3 µm in diameter. Platelets circulate in the blood of mammals and are involved in hemostasis and lead to the formation of blood clots.
Platelets provide the necessary hormones and proteins for coagulation. Collagen is released when the lining of a blood vessel is damaged. The platelet recognizes collagen and begins to work on coagulating the blood by forming a kind of stopper, so further damage to the blood vessel is prevented.
How platelets are produced?
Platelets are either removed from collected units of whole and pooled to make a therapeutic dose or is collected from the process of apheresis.
The pooled whole blood platelets also known as random platelets can be produced using two methods. A unit of whole blood is placed into a centrifuge and goes through the process of a “soft spin”. At these settings the platelets stay suspended in the plasma. The platelet rich plasma is then removed from the red blood cells. It is then centrifuged at a faster setting to collect the platelets from the plasma.
In the second method, the unit of whole blood is centrifuged using settings that cause the platelets to become suspended in the “buffy coat layer”. This layer contains the platelets and white blood cells. The “buffy coat” is put in a sterile bag and then suspended in a small amount of red blood cells and plasma. It is then centrifuged again to separate the red and white blood cells from the platelets and plasma.
In spite of the method used for preparation, the platelets can be combined into one container using a sterilized connection device to make a single product with the required dosage.
|Whole Blood in collection Tube |Blood after Centrifugation |Buffy Coat and RBCs |Top View of buffy coat |
|[pic] |[pic] |[pic] |[pic]...
The 2 blood products I have chosen are platelets and plasma
Platelets
Platelets are small clear cell fragments about 2-3 µm in diameter. Platelets circulate in the blood of mammals and are involved in hemostasis and lead to the formation of blood clots.
Platelets provide the necessary hormones and proteins for coagulation. Collagen is released when the lining of a blood vessel is damaged. The platelet recognizes collagen and begins to work on coagulating the blood by forming a kind of stopper, so further damage to the blood vessel is prevented.
How platelets are produced?
Platelets are either removed from collected units of whole and pooled to make a therapeutic dose or is collected from the process of apheresis.
The pooled whole blood platelets also known as random platelets can be produced using two methods. A unit of whole blood is placed into a centrifuge and goes through the process of a “soft spin”. At these settings the platelets stay suspended in the plasma. The platelet rich plasma is then removed from the red blood cells. It is then centrifuged at a faster setting to collect the platelets from the plasma.
In the second method, the unit of whole blood is centrifuged using settings that cause the platelets to become suspended in the “buffy coat layer”. This layer contains the platelets and white blood cells. The “buffy coat” is put in a sterile bag and then suspended in a small amount of red blood cells and plasma. It is then centrifuged again to separate the red and white blood cells from the platelets and plasma.
In spite of the method used for preparation, the platelets can be combined into one container using a sterilized connection device to make a single product with the required dosage.
|Whole Blood in collection Tube |Blood after Centrifugation |Buffy Coat and RBCs |Top View of buffy coat |
|[pic] |[pic] |[pic] |[pic]...