Effects of a Preincisional 14 Day Course of Valerian on Natural Killer Cell Activity in Sprague-Dawley Male Rats Undergoing Abdominal Surgery
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Effects of a Preincisional 14 day course of Valerian on Natural Killer Cell Activity in Sprague-Dawley Male Rats Undergoing Abdominal Surgery
Authors:
COL (ret) Norma Lynn Garrett, CRNA, PhD, USA, AN
Fort Sam Houston, Texas
LTC (ret) Nathaniel M. Apatov, CRNA, PhD, USA, AN
Tripler Army Medical Center, HI
CPT Robert Fredregill, SRNA, BSN, USA, AN
Tripler Army Medical Center, HI
CPT Aaron Johnston, BSN, USA, AN
Tripler Army Medical Center, HI
CPT John Buen, SRNA, BSN, USA, AN
USUHS, Graduate School of Nursing, Nurse Anesthesia Program, Bethesda, Maryland
CPT Michael Neill, SRNA, BSN, USA, AN
Tripler Army Medical Center, HI
Patricia S. Dixon, MS
Affiliation:
U.S. Army/University of Texas Health Science Center at Houston Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas
Introduction: The American Cancer Society estimated that over one million new cancer cases were diagnosed in 2005 and a majority of these patients died from metastatic spread.1 The standard for treating solid tumor cancer is surgical resection. However, it has been suggested that surgical resection may in fact promote metastasis.2 One of the body’s natural defenses to combat metastasis is the activity of natural killer (NK) cells. NK cells serve as a vital mediator of detection during the early innate immune response and destruction of aberrant cells. It has been demonstrated that benzodiazepines may ameliorate surgery-induced suppression of natural killer cell activity.3 We examined the effect of a 14-day course of valerian, an herbal anxiolytic, on natural killer cell activity in Sprague-Dawley rats.
Methods: Thirty-five rats were assigned to one of three groups: 1) surgical animals administered research grade valerian, 15 mg/kg solubilized in peanut oil 2) surgical animals administered peanut oil (vehicle) and 3) anesthesia only animals administered valerian. One day prior to the 14 day course of valerian, blood was drawn to assay baseline NK...
Authors:
COL (ret) Norma Lynn Garrett, CRNA, PhD, USA, AN
Fort Sam Houston, Texas
LTC (ret) Nathaniel M. Apatov, CRNA, PhD, USA, AN
Tripler Army Medical Center, HI
CPT Robert Fredregill, SRNA, BSN, USA, AN
Tripler Army Medical Center, HI
CPT Aaron Johnston, BSN, USA, AN
Tripler Army Medical Center, HI
CPT John Buen, SRNA, BSN, USA, AN
USUHS, Graduate School of Nursing, Nurse Anesthesia Program, Bethesda, Maryland
CPT Michael Neill, SRNA, BSN, USA, AN
Tripler Army Medical Center, HI
Patricia S. Dixon, MS
Affiliation:
U.S. Army/University of Texas Health Science Center at Houston Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas
Introduction: The American Cancer Society estimated that over one million new cancer cases were diagnosed in 2005 and a majority of these patients died from metastatic spread.1 The standard for treating solid tumor cancer is surgical resection. However, it has been suggested that surgical resection may in fact promote metastasis.2 One of the body’s natural defenses to combat metastasis is the activity of natural killer (NK) cells. NK cells serve as a vital mediator of detection during the early innate immune response and destruction of aberrant cells. It has been demonstrated that benzodiazepines may ameliorate surgery-induced suppression of natural killer cell activity.3 We examined the effect of a 14-day course of valerian, an herbal anxiolytic, on natural killer cell activity in Sprague-Dawley rats.
Methods: Thirty-five rats were assigned to one of three groups: 1) surgical animals administered research grade valerian, 15 mg/kg solubilized in peanut oil 2) surgical animals administered peanut oil (vehicle) and 3) anesthesia only animals administered valerian. One day prior to the 14 day course of valerian, blood was drawn to assay baseline NK...