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- Submitted by: marijay
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- Category: English
- Date Submitted: 08/21/2010 09:33 PM
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* analyse information from secondary sources to outline the evidence that led to Beadle and Tatum’s ‘one gene – one protein’ hypothesis and to explain why this was altered to the ‘one gene – one polypeptide’ hypothesis
Beadle & Tatum (1941) conducted research to determine if & how genes control biochemical reactants.
* They hypothesized that if there really was a one-to-one relationship between genes and specific enzymes, it should be possible to create genetic mutants that are unable to carry out specific enzymatic reactions.
They:
* used bread mould to investigate nutritional mutations (because bread mould was easy to maintain & induce mutation)
* using X-rays, they produced mould that was unable to produce a specific amino acid (a mutant mould). The mould was unable grow unless the amino acid was added.
* Beadle & Tatum hypothesised that this mutant mould had lost the ability to make the enzyme to create the amino acid (since the X-rays had mutated the gene).
* They then hypothesised that for each gene, there was one enzyme (protein).
* This was later changed to ‘one gene – one polypeptide.’ This was because the enzymes they studied consisted of one polypeptide, BUT many enzymes consist of chains of polypeptides.
MODIFIED because: many proteins are comprised of more than one polypeptide that may be same/ different.
Beadle & Tatum showed that genes controlled biochemical processes.
* Beadle and Tatum (1930’s-40’s) set out to provide experimental proof of the connection between genes and enzymes.
* They hypothesized that if there really was a one-to-one relationship between genes and specific enzymes, it should be possible to create genetic mutants that are unable to carry out specific enzymatic reactions.
* To test this theory, they exposed spores of Neurospora crassa (a bread mould) to X-rays or UV radiation. (because bread mould was easy to maintain & induce mutation)
* The...
Beadle & Tatum (1941) conducted research to determine if & how genes control biochemical reactants.
* They hypothesized that if there really was a one-to-one relationship between genes and specific enzymes, it should be possible to create genetic mutants that are unable to carry out specific enzymatic reactions.
They:
* used bread mould to investigate nutritional mutations (because bread mould was easy to maintain & induce mutation)
* using X-rays, they produced mould that was unable to produce a specific amino acid (a mutant mould). The mould was unable grow unless the amino acid was added.
* Beadle & Tatum hypothesised that this mutant mould had lost the ability to make the enzyme to create the amino acid (since the X-rays had mutated the gene).
* They then hypothesised that for each gene, there was one enzyme (protein).
* This was later changed to ‘one gene – one polypeptide.’ This was because the enzymes they studied consisted of one polypeptide, BUT many enzymes consist of chains of polypeptides.
MODIFIED because: many proteins are comprised of more than one polypeptide that may be same/ different.
Beadle & Tatum showed that genes controlled biochemical processes.
* Beadle and Tatum (1930’s-40’s) set out to provide experimental proof of the connection between genes and enzymes.
* They hypothesized that if there really was a one-to-one relationship between genes and specific enzymes, it should be possible to create genetic mutants that are unable to carry out specific enzymatic reactions.
* To test this theory, they exposed spores of Neurospora crassa (a bread mould) to X-rays or UV radiation. (because bread mould was easy to maintain & induce mutation)
* The...