Lipogenesis
- Submitted by: nickyc
- Views: 247
- Category: Science
- Date Submitted: 01/02/2015 02:30 AM
- Pages: 8
- Report this Essay
Introduction
The following assumptions have been made concerning Mrs Jones age, diet and health status.
1) That she is aged between 19 and 64, as per Food Standards Agency dietary advice for adults. (Food Standards Agency 2007).
2) That her average calorific intake is as currently recommended by the Scientific Advisory Committee on Nutrition (SACN), who’s draft paper recommends that the original 1991 advice from the Committee on Medical Aspects of Food Policy (COMA) suggested intake of 2000 calories for women had actually been underestimated due to flawed methodology and as such a further 16% or approximately 320 calories is notionally required, bringing the total to 2320 calories within a 24 hour period (Scientific Advisory Committee on Nutrition 2014).
3) Is of good health with no underlying chronic or long term conditions such as cardiovascular disease or diabetes.
4) Has a reasonable level of activity, following recommendations by SACN ‘which state that adults should do at least 30 minutes of moderate-intensity activity five or more days a week’ NHS (2009).
The mechanism that explains why Mrs Jones is still creating adipose tissue despite her low fat diet is called Lipogenesis.
A definition is ‘Lipogenesis encompasses the process of fatty acid synthesis and subsequent triglyceride synthesis and takes place in both liver and adipose tissue’ (Kersten, S 2001).
Essentially the accumulation of fat tissue is determined by the balance between lipogenesis and lipolysis (fatty acid oxidation). In Mrs Jones case the relationship between these two metabolic pathways is more heavily weighted in favour of lipogenesis hence the accumulation of adipose tissue.
Her high carbohydrate intake is directly stimulating the lipogenic pathway, which is mediated by hormonal controls such as Growth Hormone and Leptin which inhibit the process and Insulin which stimulates it (Kersten, S 2001).
Since the assumption is that Mrs Jones is consuming a high...
The following assumptions have been made concerning Mrs Jones age, diet and health status.
1) That she is aged between 19 and 64, as per Food Standards Agency dietary advice for adults. (Food Standards Agency 2007).
2) That her average calorific intake is as currently recommended by the Scientific Advisory Committee on Nutrition (SACN), who’s draft paper recommends that the original 1991 advice from the Committee on Medical Aspects of Food Policy (COMA) suggested intake of 2000 calories for women had actually been underestimated due to flawed methodology and as such a further 16% or approximately 320 calories is notionally required, bringing the total to 2320 calories within a 24 hour period (Scientific Advisory Committee on Nutrition 2014).
3) Is of good health with no underlying chronic or long term conditions such as cardiovascular disease or diabetes.
4) Has a reasonable level of activity, following recommendations by SACN ‘which state that adults should do at least 30 minutes of moderate-intensity activity five or more days a week’ NHS (2009).
The mechanism that explains why Mrs Jones is still creating adipose tissue despite her low fat diet is called Lipogenesis.
A definition is ‘Lipogenesis encompasses the process of fatty acid synthesis and subsequent triglyceride synthesis and takes place in both liver and adipose tissue’ (Kersten, S 2001).
Essentially the accumulation of fat tissue is determined by the balance between lipogenesis and lipolysis (fatty acid oxidation). In Mrs Jones case the relationship between these two metabolic pathways is more heavily weighted in favour of lipogenesis hence the accumulation of adipose tissue.
Her high carbohydrate intake is directly stimulating the lipogenic pathway, which is mediated by hormonal controls such as Growth Hormone and Leptin which inhibit the process and Insulin which stimulates it (Kersten, S 2001).
Since the assumption is that Mrs Jones is consuming a high...