George is a migrant worker who travels from farm to farm with his mentally impaired friend Lennie during the Depression. The two dream of earning enough money to buy a small farm where Lennie can tend rabbits. By virtue of his mental superiority, George assumes a dominant role with Lennie, acting as a parent. Because Lennie tends to involve George in difficult predicaments, George must be responsible, level-headed and ready to deal with any tragedy that may arise. Despite the many problems that Lennie causes George, he stays with his simple-minded friend as a buffet against loneliness and he retains a hope that the two will eventually leave the aimless life of a migrant worker to live a more fulfilling existence.
Lennie is a gigantic, mentally disabled man, Lennie is simplistic and docile. He obsesses over simple sensory pleasures, particularly finding great joy in touching soft things, whether a cotton dress or a soft puppy. Although Lennie is inherently innocent, he is still capable of great violence, for he lacks the capacity to control himself physically and has a great protective instinct, especially when it comes to his friend, George. Lennie dreams with George of having a small piece of land; he is obsessed with one aspect of this dream: having a small rabbit hutch where he can tend rabbits. Lennie is incapable of making decisions by himself and relies on George entirely to help him out of tough situations.